22.08.24
KhoomAbstract
Hluav taws xob stimulation ntawm invasive microelectrodes feem ntau yog siv los kho ntau yam ntawm neurological thiab puas hlwb.Txawm hais tias nws txoj kev vam meej zoo kawg li, qhov kev ua haujlwm stimulation tsis ruaj khov vim tias cov electrodes tau encapsulated los ntawm gliosis vim txawv teb chaws lub cev.Sib nqus stimulation kov yeej cov kev txwv no los ntawm kev tshem tawm qhov xav tau ntawm kev sib cuag hlau-electrode.Ntawm no, peb ua qauv qhia tshiab microfabricated solenoid inductor (80 µm × 40 µm) nrog cov tub ntxhais sib nqus uas tuaj yeem qhib cov ntaub solenoid.
Implantable micromagnetic stimulation (µMS) muaj ntau yam zoo dua li electrode stimulation.Kev txhim kho hauv nanofabrication thev naus laus zis tau tso cai rau peb los tsim ultrasmall solenoids nrog cov hlau nplaum sib nqus uas tuaj yeem tsim cov hlau nplaum loj dua thaum ua tiav hauv cov txheej txheej biocompatible.Novel microfabricated solenoid tau ua tiav cov ntaub solenoid ua tiav thiab yog li qhia tau tias muaj peev xwm ua tau lwm txoj hauv kev rau cov cuab yeej neural interfacing tam sim no rau cov kev siv neuroscience thiab kev kho mob, txawm tias yuav tsum tau tshawb nrhiav ntxiv.
Fig.a Qhov teeb tsa siv los ntsuas qhov sib nqus flux ntom nti tawm los ntawm cov tshiab microsolenoid siv cov kev cai tsim raws li NV pob zeb diamond sensor.b Lub qhov rai scan tau pom siv hauv kev teeb tsa (a).c Kev teeb tsa siv pov thawj-ntawm-lub tswv yim ntawm µMS siv cov micro/macrosolenoids hauv cov hlwb mob hnyav
Fig.Epifluorescence micrograph ntawm lub hlwb hlais los ntawm Thy1-GCaMP6s transgenic nas uas qhia txog kev hloov pauv hauv fluorescence teb rau µMS thaum siv lub (sab saum toj) macrosolenoid thiab (hauv qab) microsolenoid
Kev tsom xam ntawm kev siv technology
CovDhyana 400BSILub koob yees duab tau siv los soj ntsuam xov tooj cua-fluorescence microscopic dluab ntawm lub hlwb hlais cov nas transgenic.Nws muaj qhov sib txawv zoo thiab rhiab heev, muab kev ua haujlwm zoo quantum thiab tsis muaj suab nrov ntawm UV wavelengths, thiab qhov siab dynamic ntau 16-ntsis hom tso cai rau cov duab ntawm qhov kaj thiab fluorescence txawm tias cov teeb liab fluorescence tsawg heev.Cov hluav taws xob hloov pauv ntawm ntau qhov sib txawv ntawm solenoids rau nas lub paj hlwb tuaj yeem pom hauv daim duab, thiaj li ua ntej txiav txim siab qhov ua tau ntawm cov tswv yim.Submillimeter thiab millimeter coils hloov cov tam sim no mus rau hauv magnetic flux, uas tom qab ntawd induces hluav taws xob teb gradient muaj zog txaus txav ions thiab thawb lawv kom nkag siab (los yog suppress) cov lus teb neuron.
Kev siv qhov chaw:
1. Khalifa, A., Zaeimbashi, M., Zhou, TX et al.Kev loj hlob ntawm microfabricated solenoids nrog cov hlau nplaum rau micromagnetic neural stimulation.Microsyst Nanoeng 7, 91 (2021).https://doi.org/10.1038/s41378-021-00320-8
